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ea0013p235 | Neuroendocrinology and behaviour (including pituitary) | SFEBES2007

Growth hormone sensitivity in GH deficient (GHD) hypopituitary adults is dependent on gender, but independent of timing of onset

Columb Breeda , Jostel Andreas , Mukherjee Annice , Smethurst Linda , Shalet Stephen , Murray Robert

Females release 23 fold greater GH compared with males whilst maintaining similar IGF-I levels. IGF-I generation tests in healthy subjects suggest this discordancy results from resistance to GH in females. In GHD females the presumed relative insensitivity to GH is reflected by a lower basal IGF-I and higher GH maintenance doses during replacement. GHD adults of childhood- (CO) and adult-onset (AO) show CO-GHD adults to have lower basal IGF-I values and require higher ma...

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ea0032p965 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Central hypothyroidism and adjusted thyroxine dose study (CHATS): impact of increasing free thyroxine levels in patients with hypopituitarism

Minder Anna-Elisabeth H , Jostel Andreas , Higham Claire E , Ryder W David J , Trainer Peter J , Shalet Stephen M

Introduction: Patients with pituitary deficiencies suffer from impaired quality of life regardless of substitution therapy with hydrocortisone, thyroxine (T4), sex hormones or GH. Central hypothyroidism (CH) is difficult to diagnose and treat because symptoms are non-specific and TSH-levels cannot be used for assessment. There is no consensus for the fT4-goal of thyroxine-replacement in patients with CH.Aim: To determine the impact ...

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Endocrine Abstracts

Growth hormone sensitivity in GH deficient (GHD) hypopituitary adults is dependent on gender, but independent of timing of onset

Central hypothyroidism and adjusted thyroxine dose study (CHATS): impact of increasing free thyroxine levels in patients with hypopituitarism

BiosciAbstracts